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Science-Packed Relief in Every Single Dose

NEM®

NEM® is the original eggshell membrane ingredient for optimal joint function and has been the leader for over 15 years. With a total of 16 published clinical trials and over 600 subjects included, it has more eggshell membrane healthy population joint health studies than any other eggshell membrane ingredient.

In human clinical trials, NEM has been shown to support healthy joints, reducing pain, stiffness, and cartilage breakdown in as little as 4-11 days.* NEM® is sustainably sourced from a renewable supply of US-domestic eggshells and is available in a convenient daily dosage of 500mg, offering extensive formulation flexibility.

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Key Facts
  • NEM®, administered in a single daily dose of 500mg, has demonstrated significant improvements in stiffness, range of motion (ROM), and pain reduction within just 7 days according to human clinical trials.
  • NEM® has a verified mechanism of action: it exhibits direct immune-modulatory effects by reducing pro-inflammatory cytokines (e.g., TNF-α, IL-1β, CRP) in human immune cells, and indirectly modulates NF-kB activation through an oral tolerance mechanism in the gut-associated lymphoid tissue (GALT).
  • NEM® delivers significant benefits as evidenced by standardized testing methodologies for joint health, including WOMAC, VAS, and Lequesne's Functional Index (LFI).
  • NEM® positively impacts pain biomarkers, specifically PGRI/PGE2 and LOX/COX, contributing to its effectiveness in managing joint health.
  • NEM® rigorously tested for purity and potency, has demonstrated an excellent safety profile in clinical trials, being well-tolerated and supported by extensive safety data.
  • NEM helps support joint health*
  • NEM may help reduce exercise induced joint pain*
  • NEM may help promote joint flexibility*
  • NEM may help reduce joint aches and pains*
  • NEM may help reduce joint stiffness*
  • Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear*
*These statements have not been evaluated by the US Food & Drug Administration or the European Food and Safety Authority. This product is not intended to diagnose, treat, cure, or prevent any disease.
1) Ruff, K.J., Morton, K., Duncan, S.A., Back, M., Ismail, A., Ryan, A.S. (2020) Eggshell Membrane+Fish Oil Combination (Move3®) Reduces Exercise-Induced Joint Pain, Stiffness and Cartilage Turnover in Healthy Adults: Results from a Randomized, Double-Blind, Placebo-Controlled Study. International Journal of Physical Medicine and Rehabilitation, 8(3), 1000551.
2) Damjanov, N., Novkovic, S., Basaric, M., Nikolic, A.K., Vagic, K., Pejnovic, N., Karic, V. (2019) NEM® Brand Eggshell Membrane in the Treatment of Pain and Stiffness Associated with Knee Osteoarthritis: An Open Label Clinical Study. Journal of Arthritis, 8(5), 1000287.
3) Eskiyurt, N., Saridoğan, Senel K., Günaydin, R., Erdal, A., Özyiğit, E., Akarirmak, Ü., Şendur, Ö., Barut, K., Gülseren, A., Özsoy, T., Tuncer, T., Karataş, Ö., İrdesel, J., Ketenci, A., and Aydogan, C. (2019) Efficacy and Safety of Natural Eggshell Membrane (NEM®) in Patients with Grade 2/3 Knee Osteoarthritis: A Multi-Center, Randomized, Double-blind, Placebo-Controlled, Single-crossover Clinical Study. Journal of Arthritis, 8(4), 1000285.
4) Ruff, K.J., Theodosakis, J., Morrison, D., Duncan, S.A., Back, M., and Aydogan, C. (2018) Eggshell Membrane: Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clinical Interventions in Aging, 13, 285-295.
5) Brunello, E., and Masini, A. (2016) NEM® Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Associated with Osteoarthritis of the Knee in an Italian Study Population. International Journal of Clinical Medicine, 7, 169- 175.
6) Danesch, U., Seybold, M., Rittinghausen, R., Treibel, W., and Bitterlich, N. (2014) NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. Journal of Arthritis, 3(3), 136.
7) Ruff, K.J., Winkler, A., Jackson, R.W., DeVore, D.P., and Ritz, B.W. (2009) Eggshell Membrane in the Treatment of Pain and Stiffness from Osteoarthritis of the Knee: A Randomized, Multicenter, Double Blind, Placebo Controlled Clinical Study. Clinical Rheumatology, 28, 907-914.
8) Ruff, K.J., DeVore, D.P., Leu, M.D., and Robinson, M.A. (2009) Eggshell Membrane: A Possible New Natural Therapeutic For Joint & Connective Tissue Disorders. Results From Two Open-label Human Clinical Studies. Clinical Interventions in Aging, 4, 235-240.
9) Wedekind, K.J., Ruff, K.J., Atwell, C.A., Evans, J.L., and Bendele, A.M. (2016) Beneficial Effects of Natural Eggshell Membrane (NEM) on Multiple Indices of Arthritis in Collagen-Induced Arthritic Rats. Modern Rheumatology, 27(5), 838- 848.
10) Sim, B.Y, Bak, J.W., Lee, H.J., Jun, J.A., Choi, H.J., Kwon, C.J., Kim, H.Y., Ruff, K.J., Brandt, K., and Kim, D.H. (2015) Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. Journal of Nutrition and Health, 48(4), 310-318.
11) Ruff, K.J., Durham, P.L., O’Reilly, A., and Long, F.D. (2015) Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy. Journal of Inflammation Research, 8, 49-57.
12) Ruff, K.J., and DeVore, D.P. (2014) Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Modern Research in Inflammation 3(1), 19-25.
13) Benson, K.F., Ruff, K.J., and Jensen, G.S. (2012) Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion. Journal of Medicinal Food, 15(4), 360-368.
14) Ruff, K.J., Back, M., Morrison, D., Duncan, S.A. (2019) Development of a Novel Clinical Trial Design to Evaluate the Effects of Joint Therapeutics on Cartilage Turnover in Healthy Subjects. Journal of Novel Physiotherapies, 9(3), 1000415.
15) Ruff, K.J., Endres, J.R., Clewell, A.E., Szabo, J.R., and Schauss, A.G. (2012) Safety evaluation of a natural eggshell membrane-derived product. Food and Chemical Toxicology, 50, 604-611.
  • 2021 NutraIngredient-USA Finalist – Ingredient of the Year: Sports Nutrition
  • 2019 NutraIngredients-USA Finalist – Nutrition Research Project: Development of a Healthy-population Clinical Model for Evaluating Joint Health Therapeutics
  • 2018 Frost & Sullivan Competitive Strategy Innovation and Leadership Award Winner: Joint Health Ingredient Industry
  • 2014 Supply Side CPG Editor’s Choice Award Winner – Redd Remedies JOINThealth Soft Chews containing NEM®
  • 2011 Frost & Sullivan North American Dietary Supplements for Joint Health New Product Innovation of the Year Award Winner
  • 2009 Frost & Sullivan North American Bone & Joint Health Promising Ingredient of the Year Award Winner
  • NEM®, administered in a single daily dose of 500mg, has demonstrated significant improvements in stiffness, range of motion (ROM), and pain reduction within just 7 days according to human clinical trials.
  • NEM® has a verified mechanism of action: it exhibits direct immune-modulatory effects by reducing pro-inflammatory cytokines (e.g., TNF-α, IL-1β, CRP) in human immune cells, and indirectly modulates NF-kB activation through an oral tolerance mechanism in the gut-associated lymphoid tissue (GALT).
  • NEM® delivers significant benefits as evidenced by standardized testing methodologies for joint health, including WOMAC, VAS, and Lequesne's Functional Index (LFI).
  • NEM® positively impacts pain biomarkers, specifically PGRI/PGE2 and LOX/COX, contributing to its effectiveness in managing joint health.
  • NEM® rigorously tested for purity and potency, has demonstrated an excellent safety profile in clinical trials, being well-tolerated and supported by extensive safety data.
  • NEM helps support joint health*
  • NEM may help reduce exercise induced joint pain*
  • NEM may help promote joint flexibility*
  • NEM may help reduce joint aches and pains*
  • NEM may help reduce joint stiffness*
  • Mechanism of action studies suggest that NEM may help reduce cartilage degradation associated with normal wear and tear*
*These statements have not been evaluated by the US Food & Drug Administration or the European Food and Safety Authority. This product is not intended to diagnose, treat, cure, or prevent any disease.
1) Ruff, K.J., Morton, K., Duncan, S.A., Back, M., Ismail, A., Ryan, A.S. (2020) Eggshell Membrane+Fish Oil Combination (Move3®) Reduces Exercise-Induced Joint Pain, Stiffness and Cartilage Turnover in Healthy Adults: Results from a Randomized, Double-Blind, Placebo-Controlled Study. International Journal of Physical Medicine and Rehabilitation, 8(3), 1000551.
2) Damjanov, N., Novkovic, S., Basaric, M., Nikolic, A.K., Vagic, K., Pejnovic, N., Karic, V. (2019) NEM® Brand Eggshell Membrane in the Treatment of Pain and Stiffness Associated with Knee Osteoarthritis: An Open Label Clinical Study. Journal of Arthritis, 8(5), 1000287.
3) Eskiyurt, N., Saridoğan, Senel K., Günaydin, R., Erdal, A., Özyiğit, E., Akarirmak, Ü., Şendur, Ö., Barut, K., Gülseren, A., Özsoy, T., Tuncer, T., Karataş, Ö., İrdesel, J., Ketenci, A., and Aydogan, C. (2019) Efficacy and Safety of Natural Eggshell Membrane (NEM®) in Patients with Grade 2/3 Knee Osteoarthritis: A Multi-Center, Randomized, Double-blind, Placebo-Controlled, Single-crossover Clinical Study. Journal of Arthritis, 8(4), 1000285.
4) Ruff, K.J., Theodosakis, J., Morrison, D., Duncan, S.A., Back, M., and Aydogan, C. (2018) Eggshell Membrane: Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clinical Interventions in Aging, 13, 285-295.
5) Brunello, E., and Masini, A. (2016) NEM® Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Associated with Osteoarthritis of the Knee in an Italian Study Population. International Journal of Clinical Medicine, 7, 169- 175.
6) Danesch, U., Seybold, M., Rittinghausen, R., Treibel, W., and Bitterlich, N. (2014) NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. Journal of Arthritis, 3(3), 136.
7) Ruff, K.J., Winkler, A., Jackson, R.W., DeVore, D.P., and Ritz, B.W. (2009) Eggshell Membrane in the Treatment of Pain and Stiffness from Osteoarthritis of the Knee: A Randomized, Multicenter, Double Blind, Placebo Controlled Clinical Study. Clinical Rheumatology, 28, 907-914.
8) Ruff, K.J., DeVore, D.P., Leu, M.D., and Robinson, M.A. (2009) Eggshell Membrane: A Possible New Natural Therapeutic For Joint & Connective Tissue Disorders. Results From Two Open-label Human Clinical Studies. Clinical Interventions in Aging, 4, 235-240.
9) Wedekind, K.J., Ruff, K.J., Atwell, C.A., Evans, J.L., and Bendele, A.M. (2016) Beneficial Effects of Natural Eggshell Membrane (NEM) on Multiple Indices of Arthritis in Collagen-Induced Arthritic Rats. Modern Rheumatology, 27(5), 838- 848.
10) Sim, B.Y, Bak, J.W., Lee, H.J., Jun, J.A., Choi, H.J., Kwon, C.J., Kim, H.Y., Ruff, K.J., Brandt, K., and Kim, D.H. (2015) Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. Journal of Nutrition and Health, 48(4), 310-318.
11) Ruff, K.J., Durham, P.L., O’Reilly, A., and Long, F.D. (2015) Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy. Journal of Inflammation Research, 8, 49-57.
12) Ruff, K.J., and DeVore, D.P. (2014) Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Modern Research in Inflammation 3(1), 19-25.
13) Benson, K.F., Ruff, K.J., and Jensen, G.S. (2012) Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion. Journal of Medicinal Food, 15(4), 360-368.
14) Ruff, K.J., Back, M., Morrison, D., Duncan, S.A. (2019) Development of a Novel Clinical Trial Design to Evaluate the Effects of Joint Therapeutics on Cartilage Turnover in Healthy Subjects. Journal of Novel Physiotherapies, 9(3), 1000415.
15) Ruff, K.J., Endres, J.R., Clewell, A.E., Szabo, J.R., and Schauss, A.G. (2012) Safety evaluation of a natural eggshell membrane-derived product. Food and Chemical Toxicology, 50, 604-611.
  • 2021 NutraIngredient-USA Finalist – Ingredient of the Year: Sports Nutrition
  • 2019 NutraIngredients-USA Finalist – Nutrition Research Project: Development of a Healthy-population Clinical Model for Evaluating Joint Health Therapeutics
  • 2018 Frost & Sullivan Competitive Strategy Innovation and Leadership Award Winner: Joint Health Ingredient Industry
  • 2014 Supply Side CPG Editor’s Choice Award Winner – Redd Remedies JOINThealth Soft Chews containing NEM®
  • 2011 Frost & Sullivan North American Dietary Supplements for Joint Health New Product Innovation of the Year Award Winner
  • 2009 Frost & Sullivan North American Bone & Joint Health Promising Ingredient of the Year Award Winner

Health Indications

Bone and Joint Health

To support bone density and joint health.

Sport Nutrition

For athletes or those looking to increase muscle mass.

Female Health

Prophylaxis, Infections, Menopause Symptoms etc. – all stages.
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Applications

We’ve unveiled the next application method for your product, tailored for optimal use.NEM’s effective 500 mg dose offers extensive formulation flexibility and a simple, once-a-day comprehensive joint health solution. While potent as a standalone ingredient, NEM also excels in unique combination formulas.At Phytonet Pharmaceuticals, we specialize in providing a wide range of forms, ensuring versatility and quality in every solution.
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